Key ingredients include a triple growth factor combination that has three of the most powerful epidermal and dermal remodeling factors which are recognized by the skin as naturally occurring reducing any risk of irritation. Epidermal Growth Factor (EGF) stimulates keratinocytes and fibroblasts, increases collagen, elastin, and hyaluronic acid. Basic Fibroblast Growth Factor (FGF), stimulates endothelial cells, fibroblasts, and keratinocytes. Insulin Growth Factor-1 significantly increases the efficacy of the EGF and FGF combination and acts as a plumping agent for photoaged skin.